APOE in Focus: Considerations and Guidelines for Genetic Testing
Nov 24, 2021
Webinar information
Date: December 15, 2021
Time: 9:00 AM PST / 18:00 CET
Duration: 1 hour
Speaker: Ison H, Jones T, Wand H, Faulkner K

Date: December 15, 2021
Time: 9:00 AM PST / 18:00 CET

Variants in APOE are known to play a role in both abnormalities of lipid metabolism and neurologic disease. While crossing medical specialties, the complexities of testing for APOE in a clinical setting are further compounded by the absence of established “actionability,” availability of information in direct-to-consumer testing, differing laboratory reporting policies, and lack of current knowledge on APOE’s effect in diverse populations. It is likely that clinicians across both specialties may encounter questions about when testing this gene is indicated, how best to counsel around this indication, and what nuances should be considered before testing.

During this webinar, Hannah Ison, MS, CGC, Tara Jones, MS, CGC, Hannah Wand, MS, CGC, and Kaylee Faulkner, MS, CGC will address these questions, review current guidelines on this topic, and present cases that demonstrate ways in which genetic counselors have encountered questions around this topic.

Webinar objectives:

  • Review APOE’s role in coronary artery disease risk and Alzheimer’s disease risk
  • Case-based discussion analyzing personal utility and clinical utility to define actionable results
  • Examine guidelines for testing APOE in clinical or direct-to-consumer testing


Hannah Ison

Hannah Ison is a cardiovascular genetic counselor at the Stanford Center for Inherited Cardiovascular Disease (SCICD), who primarily specializes in working with patients who have inherited cholesterol conditions. Her interest in this specialty began as a volunteer in the Inherited Lipid Clinic at SCICD, where she had the opportunity to assist with Stanford's Find FH project and CASCADE FH registry. She was then accepted into Indiana University's Genetic Counseling graduate program and assisted with the development of the Lipid Clinic at this institution. Following graduation, she was offered a genetic counseling position in the Inherited Lipid Clinic at SCICD, and is currently developing a pediatric lipid clinic at Lucile Packard Children's Hospital.

Tara Jones

Tara Jones (she/her) is a genetic counselor in adult neurology at Cedars-Sinai in Los Angeles, specializing in neuromuscular and dementia indications. Tara currently serves as co-chair for a workgroup that advocates and supports genetic counselors newly entering the neurology specialty. Her research interests include data-driven service delivery models to improve patient and provider outcomes regarding pre-symptomatic genetic testing. Her clinical passion involves removing the stigma from a dementia diagnosis to allow for early detection and full involvement of persons with dementia in their own care plan.

Hannah Wand

Hannah Wand, MS, CGC, is program director of the preventive genomics program at Stanford Medicine. She is a genetic counselor in preventive cardiology and clinical instructor with an MS in genetic counseling program at Stanford. Her research interest areas are in implementation science, community engagement, and health equity within public health genomics.

Kaylee Faulkner

Kaylee Faulkner, MS, CGC attended graduate school at Arcadia University. She previously worked as a clinical genetic counselor in adult neurology. Currently, she is a genetic services consultant at Blueprint Genetics serving as a resource for neurodegenerative diseases and testing, while also partnering with clinicians across the Midwest to support their practices. She is passionate about ending patients’ diagnostic odysseys through comprehensive and quality testing and provider education.

Last modified: December 17, 2021