Germline Predisposition to Hematopoietic Malignancies
Hematopoietic malignancies or cancers of the blood forming tissue account for 6.5% of all cancers worldwide. In recent years, multiple genes causing these malignancies have been identified such as CEBPA, RUNX1, ANKRD26 and DDX41.
In this educational webinar, Lucy Godley, MD, PhD, will present a description of inherited risk to hematopoietic malignancies, including her recent work on how common inherited risk occurs in myelodysplastic syndromes. She will also feature a description of the most common disorders seen in adults – germline mutations in DDX41 and in genes encoding components of the homologous recombination DNA repair pathway. Finally, she will describe her groups’ recommendations for prioritizing which patients should be tested and how to manage them once a diagnosis of an inherited disorder has been made.
- To understand the major inherited risk disorders in adults with hematopoietic malignancies
- To learn about recent studies aimed at determining the frequency of these gene mutations
- To present a prioritization and management strategy that can be implemented
Interested in learning more? Explore our on-demand webinars by clicking, here.
Lucy Godley received scientific training in the Marchesi (Yale), Wiley (Harvard), and Varmus (UCSF/NIH) laboratories and medical training at Northwestern. After training in Internal Medicine and Hematology-Oncology at The University of Chicago, she joined the faculty, where she studies the mechanism of inherited hematopoietic malignancies and how differentiation potential is controlled by covalently modified cytosines.